Reaktion #67431

Reaktionsgleichung

(4′-cyano-biphenyl-3-yl)-carbamic acid tert-butyl ester

→

(4′-aminomethyl-biphenyl-3-yl)-carbamic acid tert-butyl ester

Lösungsmittel

EtOH

NH3.H2O

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe catalyst was filtered off
2. 2
   Einengenthe filtrate was concentrated to dryness

Vorschrift

A suspension of (4′-cyano-biphenyl-3-yl)-carbamic acid tert-butyl ester (7.6 g, 26 mmol) and Raney Ni (1 g) in EtOH (500 mL) and NH3.H2O (10 mL) was hydrogenated under 50 psi of H2 at 50° C. for 6 h. The catalyst was filtered off and the filtrate was concentrated to dryness to give (4′-aminomethyl-biphenyl-3-yl)-carbamic acid tert-butyl ester, which was used directly in next step.

Quelle