Reaktion #673885

Reaktionsgleichung

Pyrrolidine

1-benzyl-4-piperidinone

→

title compound

Ausbeute 102.0%

1-Benzyl-4-(1-pyrrolidinyl)-1,2,3,6-tetrahydropyridine

Ausbeute 102.0%

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture refluxed under Dean-Stark conditions for 4.5 hours
2. 2
   Einengenconcentrated under reduced pressure

Vorschrift

Pyrrolidine (31.8 mL, 0.38 mol) was added to a solution of 1-benzyl-4-piperidinone (48.0 g, 0.25 mol) in toluene (180 mL) and the mixture refluxed under Dean-Stark conditions for 4.5 hours. The reaction mixture was allowed to cool to room temperature and concentrated under reduced pressure to give the title compound as an orange oil (61.8 g, 100%).

Quelle