Reaktion #67279

Reaktionsgleichung

Water

KOH

5-bromo-3-fluoro-2-(oxiran-2-ylmethoxy)phenyl acetate

water KOH

→

title compound

Ausbeute 35.0%

(7-BROMO-5-FLUORO-2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL)METHANOL

Ausbeute 35.0%

Lösungsmittel

dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionthe solution was extracted with EtOAc
2. 2
   WaschenThe combined organic phases were washed with brine
3. 3
   Sonstigedried
4. 4
   Sonstigeevaporated to dryness

Vorschrift

5-bromo-3-fluoro-2-(oxiran-2-ylmethoxy)phenyl acetate (2.6 g, 8.7 mmol) was stirred in dioxane at RT. Aqueous KOH (10%) was added until basic pH was reached (1:1 water/KOH (10%)). Water was added and the solution was extracted with EtOAc: The combined organic phases were washed with brine, dried and evaporated to dryness to give the title compound (0.8 g). MS m/z (rel. intensity, 70 eV) 263 (M+, 97), 262 (M+, bp), 218 (39), 207 (50), 206 (51).

Quelle