Reaktion #67265

Reaktionsgleichung

5-bromo-2-hydroxybenzaldehyde

(S)-glycidyltosylate

K2CO3

DMF

→

crude title compound

Ausbeute 107.6%

5-BROMO-2-[(2S)-OXIRAN-2-YLMETHOXY]BENZALDEHYDE

Ausbeute 107.6%

Lösungsmittel

Water

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigePreparation
2. 2
   Extraktionthe solution was extracted with EtOAc (3×100 ml)
3. 3
   WaschenThe combined organic phases were washed with LiCl (5%, 100 ml), HCl (1 N, 100 ml), brine
4. 4
   Sonstigewere dried
5. 5
   Einengenconcentrated

Vorschrift

Preparation according to Preparation 1 using 5-bromo-2-hydroxybenzaldehyde (6 g, 30 mmol), (S)-glycidyltosylate (8.2 g, 36 mmol), K2CO3 (4.9 g, 36 mmol) and DMF (12 ml). Water (100 ml) was added and the solution was extracted with EtOAc (3×100 ml). The combined organic phases were washed with LiCl (5%, 100 ml), HCl (1 N, 100 ml), brine, were dried and concentrated to give the crude title compound (8.3 g). MS m/z (rel. intensity, 70 eV) 257 (M+, 38), 256 (M+, 39), 200 (bp), 199 (87), 57 (88).

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