Reaktion #672177

Reaktionsgleichung

2-benzyloxy-5-bromobenzaldehyde

methylamine hydrochloride

sodium cyanoborohydride

→

N-(2-Benzyloxy-5-bromo benzyl)-N-methylamine

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeafter purification by chromatography on a column of silica
2. 2
   Wascheneluted with a dichloromethane/methanol mixture (9/1) and 0.5% isopropylamine, 12.2 g (51%) of the expected product
3. 3
   Sonstigeare obtained in the form of a pale yellow oil

Vorschrift

In a manner similar to that of Example 75(b), by reacting 22.5 g (77 mmol) of 2-benzyloxy-5-bromobenzaldehyde, 26.1 g (386 mmol) of methylamine hydrochloride and 7.3 g (116 mmol) of sodium cyanoborohydride, and after purification by chromatography on a column of silica eluted with a dichloromethane/methanol mixture (9/1) and 0.5% isopropylamine, 12.2 g (51%) of the expected product are obtained in the form of a pale yellow oil.

Quelle