Reaktion #671124

Reaktionsgleichung

Na2SO3

NaHCO3

4-methoxy-3-nitrobenzenesulfonyl chloride

→

desired product

sodium 4-methoxy-3-nitrobenzenesulfinate

Lösungsmittel

H2O

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooled to room temperature
2. 2
   Waschenwashed with dichloromethane
3. 3
   WaschenThe aqueous wash
4. 4
   Filtrationwas filtered through cotton
5. 5
   Filtrationfiltered
6. 6
   Einengenconcentrated
7. 7
   Sonstigedried under vacuum

Vorschrift

A solution of Na2SO3 (400 mg, 3.2 mmol) and NaHCO3 (270 mg, 3.2 mmol) in H2O (10 mL) was treated slowly with a solution of 4-methoxy-3-nitrobenzenesulfonyl chloride (400 mg, 1.6 mmol) in acetone (3 mL), heated to 50° C. for 2 hours, cooled to room temperature, and washed with dichloromethane. The aqueous wash was filtered through cotton, lyophilized, suspended in methanol, filtered, concentrated, and dried under vacuum to provide the desired product.

Quelle