Reaktion #6710

Reaktionsgleichung

N-Methyl-piperidine-2-carboxylic acid ethyl ester

NaOH

hydrochloric acid

→

N-methyl-piperidine-2-carboxylic acid

Lösungsmittel

methanol

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeevaporated to dryness
2. 2
   Sonstigeevaporated four times with toluene

Vorschrift

N-Methyl-piperidine-2-carboxylic acid ethyl ester (5.1 g) was dissolved in a mixture of 100 ml methanol and 10 ml water. NaOH (8 g) was added and the reaction mixture was stirred at room temperature overnight. The solution was then neutralized with hydrochloric acid, evaporated to dryness, and evaporated four times with toluene. The resulting powdery residue was used directly in the next step.

Quelle