Reaktion #670906

Reaktionsgleichung

[2,2′]bipyrrolidinyl

potassium carbonate

para-fluoronitrobenzene

→

mixture

Ausbeute 37.5%

1,1′-bis(4-nitrophenyl)[2,2′]bipyrrolidinyl

Ausbeute 37.5%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe agglomerate formed
2. 2
   Filtrationwas filtered off
3. 3
   Waschenrinsed with acetone and isopropanol

Vorschrift

2.6 g (˜15 mmol) of [2,2′]bipyrrolidinyl (1) obtained above were refluxed in the presence of 5 g (35.7 mmol) of potassium carbonate and 5 g (35.7 mmol) of para-fluoronitrobenzene in 25 ml of water overnight. The agglomerate formed was filtered off and then rinsed with acetone and isopropanol to give 2.15 g of a mixture of two isomers (55/45) (44%). After purification by chromatography on silica gel, a majority isomer was isolated (1.2 g), the analyses for which were:

Quelle