Reaktion #670778

Reaktionsgleichung

AlCl3

1,2,3-trimethylbenzene

2-bromoisobutyryl bromide

→

2,5,6,7-Tetramethyl-1-Indanone

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwhile cooling with ice
2. 2
   workup.WAITThe mixture was kept at room temperature for a further 15 hours
3. 3
   workup.DISTILLATIONThe crude product was purified by distillation (0.05 mm Hg/96-107° C.)

Vorschrift

17.3 g (125 mmol) of AlCl3 were added to a solution of 6.01 g (50 mmol) of 1,2,3-trimethylbenzene in 30 ml of analytical grade methylene chloride, while cooling with ice. 11.9 g (52 mmol) of 2-bromoisobutyryl bromide were then added rapidly, and stirring was continued at 0° C. for 1 hour and at room temperature for 2 hours. The mixture was kept at room temperature for a further 15 hours and then worked up analogously to Example A. The crude product was purified by distillation (0.05 mm Hg/96-107° C.). The yield was 8.1 g (86%).

Quelle