Reaktion #669762

Reaktionsgleichung

ethyl acetate

4-bromobenzyl amine

3-cyanophenyl isocyanate

dimethylformamide

hydrochloric acid

→

N-(3-cyanophenyl)-N'-(methyl(4-bromo)phenyl)urea

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenThe ethyl acetate solution was washed with water (5×100 mL)
2. 2
   Trocknendried (MgSO4)
3. 3
   Sonstigeevaporated

Vorschrift

A mixture of 4-bromobenzyl amine (3.81 g, 20 mmol) and 3-cyanophenyl isocyanate (2.65 g, 18.4 mmol) in dimethylformamide (60 mL) was stirred at ambient temperature for 48 h. The reaction was partioned between 1N hydrochloric acid solution (200 mL) and ethyl acetate (200 mL). The ethyl acetate solution was washed with water (5×100 mL), then dried (MgSO4) and evaporated to give 5.33 g of N-(3-cyanophenyl)-N'-(methyl(4-bromo)phenyl)urea.

Quelle