Reaktion #66969

ord-b98f938669b741078b29ae3d9c919fb1

Reaktionsgleichung

CCOC(=O)Cc1ccc(OC)c(-c2ccc(C(F)(F)F)cc2CBr)c1
(2′-bromomethyl-6-methoxy-4′-trifluoromethyl-biphenyl-3-yl)-acetic acid ethyl ester
Cc1nnc(S)s1
5-methyl-1,3,4-thiadiazole-2-thiol
→
CCOC(=O)Cc1ccc(OC)c(-c2ccc(C(F)(F)F)cc2CSc2nnc(C)s2)c1
[6-Methoxy-2′-(5-methyl-[1,3,4]thiadiazol-2-ylsulfanylmethyl)-4′-trifluoromethyl-biphenyl-3-yl]acetic acid ethyl ester

Edukte

CCOC(=O)Cc1ccc(OC)c(-c2ccc(C(F)(F)F)cc2CBr)c1
(2′-bromomethyl-6-methoxy-4′-trifluoromethyl-biphenyl-3-yl)-acetic acid ethyl ester
Cc1nnc(S)s1
5-methyl-1,3,4-thiadiazole-2-thiol

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigePrepared

Vorschrift

Prepared according to the procedure described in Example 1, Step 6, using the following starting materials: (2′-bromomethyl-6-methoxy-4′-trifluoromethyl-biphenyl-3-yl)-acetic acid ethyl ester and 5-methyl-1,3,4-thiadiazole-2-thiol.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08524748B2uspto-grants-2013_09