Reaktion #66938

Reaktionsgleichung

165

2-(3-Benzyloxy-5-methoxyphenyl)-6,7-methylenedioxyquinolin-4-one

→

166

Ausbeute 77.0%

2-(3-Hydroxy-5-methoxyphenyl)-6,7-methylenedioxyquinolin-4-one

Ausbeute 77.0%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe precipitate were collected
2. 2
   workup.DISSOLUTIONdissolved in 10% NaOH solution
3. 3
   Filtrationfiltered
4. 4
   Sonstigethe precipitate was then collected
5. 5
   Waschenwashed with acetone and water

Vorschrift

A suspension of 0.5 g (1.245 mmol) of 165 and 0.25 g of palladium (10 wt % on activated carbon) in 60 mL of methanol was stirred at room temperature under hydrogen gas atmosphere for 24 h. The precipitate were collected and dissolved in 10% NaOH solution and then filtered. The filtrate was acidified with dil aq HCl and the precipitate was then collected and washed with acetone and water to give 166.

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