Reaktion #66934

Reaktionsgleichung

methyl 3-(benzyloxy)-5-methoxybenzoate

Methyl 3-(benzyloxy)-5-methoxybenzoate

sodium hydroxide

→

162

Ausbeute 90.0%

3-(Benzyloxy)-5-methoxybenzoic acid

Ausbeute 90.0%

Lösungsmittel

water

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was heated
2. 2
   Temperaturat reflux for 1 h
3. 3
   SonstigeAfter the mixture was evaporated
4. 4
   Sonstigethe residue was quenched with 150 mL of water
5. 5
   Sonstigethe precipitate was collected
6. 6
   Waschenwashed with water and acetone

Vorschrift

4.45 g (0.0174 mmol) of methyl 3-(benzyloxy)-5-methoxybenzoate (161) was suspended in 120 mL of 95% ethanol and 5 mL water. An amount of 2.00 g (0.05 mmol) of sodium hydroxide was added. The mixture was heated at reflux for 1 h. After the mixture was evaporated, the residue was quenched with 150 mL of water. The solution was neutralized with dil aq HCl and then the precipitate was collected and washed with water and acetone to give 162.

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