Reaktion #669071

Reaktionsgleichung

5-ethyl-6-(3,5-dimethylbenzoyl)-2,4-pyrimidinedione

2-(cyclopentyl)ethyl toluenesulfonate

sodium bicarbonate

lithium iodide

→

solid

Ausbeute 24.5%

1-(2-Cyclopentyl)ethyl-5-ethyl-6-(3,5-dimethylbenzoyl)-2,4-pyrimidinedione

Ausbeute 24.5%

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenconcentrated for removement of dimethylformamide
2. 2
   Extraktionextracted with dichloromethane
3. 3
   Sonstigedried
4. 4
   Filtrationfiltered
5. 5
   Sonstigeseparated by column chromatography

Vorschrift

A mixture of sodium bicarbonate (0.10 g, 1.2 mmol) and lithium iodide (13 mg, 0.1 mmol) were added to dimethylformamide solution (10 ml) of 5-ethyl-6-(3,5-dimethylbenzoyl)-2,4-pyrimidinedione (0.27 g, 1.0 mmol) and 2-(cyclopentyl)ethyl toluenesulfonate (0.27 g, 1.0 mmol). And then, the reaction mixture was stirred at 90° C. for overnight, concentrated for removement of dimethylformamide, extracted with dichloromethane, dried, filtered and separated by column chromatography to give a white solid (90 mg).

Quelle