Reaktion #669059

ord-62d2525d6ff54071955c2f48e897da39

Reaktionsgleichung

CCc1c(C(=O)c2cc(C)cc(C)c2)[nH]c(=O)[nH]c1=O
5-Ethyl-6-(3,5-dimethylbenzoyl)-2,4-pyrimidinedione
CC(C)(C)[Si](C)(C)OCC1C=C(CBr)CC1CO[Si](C)(C)C(C)(C)C
[3,4-di(t-butyldimethylsilyloxymethyl)cyclopent-1-en-1-yl]methyl bromide
→
CCc1c(C(=O)c2cc(C)cc(C)c2)n(CC2=CC(CO)C(CO)C2)c(=O)[nH]c1=O
titled compound
Ausbeute 25.0%
CCc1c(C(=O)c2cc(C)cc(C)c2)n(CC2=CC(CO)C(CO)C2)c(=O)[nH]c1=O
1-{[3,4-Di(hydroxymethyl)cyclopent-1-en-1-yl]methyl}-5-ethyl-6-(3,5-dimethylbenzoyl)-2,4-pyrimidinedione
Ausbeute 25.0%

Edukte

CCc1c(C(=O)c2cc(C)cc(C)c2)[nH]c(=O)[nH]c1=O
5-Ethyl-6-(3,5-dimethylbenzoyl)-2,4-pyrimidinedione
CC(C)(C)[Si](C)(C)OCC1C=C(CBr)CC1CO[Si](C)(C)C(C)(C)C
[3,4-di(t-butyldimethylsilyloxymethyl)cyclopent-1-en-1-yl]methyl bromide

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

5-Ethyl-6-(3,5-dimethylbenzoyl)-2,4-pyrimidinedione and [3,4-di(t-butyldimethylsilyloxymethyl)cyclopent-1-en-1-yl]methyl bromide were reacted by the same method with example 28 to obtain the titled compound (68 mg).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05922727uspto-grants-1999_07