Reaktion #669001

Reaktionsgleichung

compound ( XV )

(±)-2-Methyl-3-(3-pyridyl)-2-azabicylo[2.2.2]octane

fumaric acid

→

compound ( XVI )

Ausbeute 120.6%

(+/-)-2-Methyl-3-(3-pyridyl)-2-azabicylo[2.2.2]octane fumarate

Ausbeute 120.6%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe resulting suspension was sonicated until complete dissolution
2. 2
   SonstigeThe solvent was removed on a rotary evaporator
3. 3
   Sonstigeto give a colorless syrup which
4. 4
   Sonstigewas crystallized from absolute ethanol

Vorschrift

To a solution of compound (XV) (120 mg, 0.495 mmol) in absolute ethanol (5 mL) was added fumaric acid (138 mg, 1.18 mmol). The resulting suspension was sonicated until complete dissolution occurred. The solvent was removed on a rotary evaporator to give a colorless syrup which was crystallized from absolute ethanol to yield 190 mg (88%) of compound (XVI). Mp=142°-143° C. 1H NMR(D2O+TSP): δ 8.71 (s, 1H), 8.64-8.62 (m, 1H), 8.30-8.22 (d, 1H), 7.79-7.72 (m, 1H), 6.60 (s, 3H), 4.58 (s, 1H), 3.90 (s, 1H), 2.90 (s, 3H), 2.80 (s, 1H), 2.46-2.38 (m, 1H), 2.10-1.95 (d, 2H), 1.92-1.62 (m, 5H).

Quelle