Reaktion #66884

Reaktionsgleichung

(2E)-4-bromobut-2-enoic acid

3-chloro-5-(5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4-ylamino)phenol hydrochloride

3-Chloro-5-(5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4-ylamino)phenol hydrochloride

4-methoxypiperidine

→

title compound

3-Chloro-5-({7-[(2E)-4-(4-methoxypiperidin-1-yl)but-2-enoyl]-5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4-yl}amino)phenol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto yield 33 mg (23%)

Vorschrift

In analogy to Example 130, the title compound was prepared from (2E)-4-bromobut-2-enoic acid (84 mg, 0.41 mmol), 3-chloro-5-(5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4-ylamino)phenol hydrochloride from Example 65A (100 mg, 0.27 mmol) and 4-methoxypiperidine (50 mg, 0.43 mmol) to yield 33 mg (23%).

Quelle