Reaktion #668128

Reaktionsgleichung

Water

2-hydroxy-5-(5-trifluoromethyl-tetrazol-1-yl)benzaldehyde

potassium carbonate

methyl iodide

→

title compound

Ausbeute 113.0%

2-Methoxy-5-(5-trifluoromethyl-tetrazol-1-yl)-benzaldehyde

Ausbeute 113.0%

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionthe mixture extracted with diethyl ether (3×50 ml)
2. 2
   WaschenThe combined organic extracts were washed with saturated brine
3. 3
   Trocknendried (Na2SO4)
4. 4
   Sonstigeevaporated

Vorschrift

A mixture of 2-hydroxy-5-(5-trifluoromethyl-tetrazol-1-yl)benzaldehyde (1.56 mmol), potassium carbonate (7.8 mmol) and methyl iodide (7.8 mmol), in acetone (25 ml) was stirred for 18 h at 23° under nitrogen. Water (150 ml) was added and the mixture extracted with diethyl ether (3×50 ml). The combined organic extracts were washed with saturated brine, dried (Na2SO4) and evaporated to give the title compound as a yellow solid (0.48 g).

Quelle