Reaktion #668126

Reaktionsgleichung

1-(4-benzyloxy-phenyl)-5-trifluoromethyl-1H-tetrazole

→

title compound

Ausbeute 99.8%

4-(5-Trifluoromethyl-tetrazol-1-yl)-phenol

Ausbeute 99.8%

Lösungsmittel

ethanol

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas hydrogenated at room temperature
2. 2
   Filtrationthe mixture was filtered
3. 3
   Sonstigethe filtrate was evaporated

Vorschrift

A solution of 1-(4-benzyloxy-phenyl)-5-trifluoromethyl-1H-tetrazole (45.3 mmol) in ethanol (100 ml) and tetrahydrofuran (100 ml) was hydrogenated at room temperature and atmospheric pressure over 10% palladium-carbon catalyst (6 g). After 2 h, the mixture was filtered and the filtrate was evaporated to give the title compound (10.4 g) as a cream solid.

Quelle