Reaktion #668058

Reaktionsgleichung

3-Benzyloxycarbonylamino-4-oxo-5-phenylacetylaminooxy-pentanoic acid, 1,1 dimethylethyl ester

→

3-benzyloxycarbonylamino-4-oxo-5-phenylacetylaminooxy-pentanoic acid

Ausbeute 34.0%

Lösungsmittel

—

trifluoroacetic acid (TFA)CH2Cl2

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeReaction
2. 2
   Einengenconcentrated
3. 3
   SonstigePurification by chromatography (SiO2, 90:9:1 CH2Cl2 -acetone-formic acid)

Vorschrift

3-Benzyloxycarbonylamino-4-oxo-5-phenylacetylaminooxy-pentanoic acid, 1,1 dimethylethyl ester (208 mg, 0.365 mmol) was taken up in 3 mL of 1:1 trifluoroacetic acid (TFA)CH2Cl2 and allowed to stir for 2 hours. Reaction was diluted with acetonitrile (MeCN) (10 mL) and concentrated. The residue was stripped down from MeCN five times. Purification by chromatography (SiO2, 90:9:1 CH2Cl2 -acetone-formic acid) afforded 3-benzyloxycarbonylamino-4-oxo-5-phenylacetylaminooxy-pentanoic acid (51 mg, 34%) as a white foam.

Quelle