Reaktion #66780

Reaktionsgleichung

CDI

thieno(3,4-c)furan-1,3-dione

3-amino-3-methylpiperidin-2,6-dione

→

solid

Ausbeute 79.1%

5-(3-methyl-2,6-dioxopiperidin-3-yl)-5H-thieno(3,4-c)pyrrole-4,6-dione

Ausbeute 79.1%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto react at room temperature for 4 h
2. 2
   Temperaturto reflux for 6 h during which time a solid
3. 3
   Sonstigeprecipitated
4. 4
   TemperaturThe reaction solution was cooled
5. 5
   Filtrationfiltered

Vorschrift

1.54 g of thieno(3,4-c)furan-1,3-dione was dissolved in 20 mL of anhydrous THF, and 1.42 g of 3-amino-3-methylpiperidin-2,6-dione was added. The reaction mixture was allowed to react at room temperature for 4 h, and 2 g of CDI and a catalytic quantity of DMAP were added. The reaction mixture was allowed to reflux for 6 h during which time a solid precipitated. The reaction solution was cooled and filtered to obtain a white solid (2.2 g). MS (m/z): 278 (M)+.

Quelle