Reaktion #66757

Reaktionsgleichung

tert-butyl 6-(5-carbamoylpyridin-2-yl)-4-oxospiro[chroman-2,4′-piperidine]-1′-carboxylate

HCl

Et2O

→

6-(4-Oxospiro[chroman-2,4′-piperidin]-6-yl)nicotinamide dihydrochloride

Lösungsmittel

dioxane

dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe resulted precipitate was collected by aeration
2. 2
   Waschenwashed with Et2O
3. 3
   Sonstigeto give

Vorschrift

To a suspension of tert-butyl 6-(5-carbamoylpyridin-2-yl)-4-oxospiro[chroman-2,4′-piperidine]-1′-carboxylate in dioxane (125 ml) was added 4N HCl in dioxane (125 ml) and the mixture was stirred for 18 h. After Et2O was added to the mixture, the resulted precipitate was collected by aeration, washed with Et2O to give intended compound as a colorless solid.

Quelle