Reaktion #66751

Reaktionsgleichung

5-bromo-2-hydroxyacetophenone

N-Boc-piperidin-4-one

pyrrolidine

MeOH

→

tert-Butyl 6-bromo-4-oxospiro[chroman-2,4′-piperidine]-1′-carboxylate

Lösungsmittel

H2O

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturunder reflux until the reaction
3. 3
   TemperaturThe mixture was cooled
4. 4
   Filtrationthe mixture was filtered
5. 5
   Sonstigedried
6. 6
   Sonstigeto give

Vorschrift

A mixture of 5-bromo-2-hydroxyacetophenone (104 g, 485 mmol), N-Boc-piperidin-4-one (98.6 g, 494 mmol), 20 mL of pyrrolidine (17.3 g, 243 mmol) and 261 mL of MeOH was heated under reflux until the reaction was complete. The mixture was cooled, then 87 mL of H2O were added, and the mixture was filtered and dried to give intended compound as a colorless solid.

Quelle