Reaktion #66722

Reaktionsgleichung

racemic ethyl 4-amino-3-methoxypiperidine-1-carboxylate

benzyl bromide

potassium carbonate

potassium iodide

→

ethyl 4-(dibenzylamino)-3-methoxypiperidine-1-carboxylate

Lösungsmittel

water

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with, for example, ethyl acetate
2. 2
   WaschenThe organic layer was washed with brine
3. 3
   Sonstigedried over anhyh
4. 4
   FiltrationSubsequent filtration and concentration of the solvent
5. 5
   Sonstigeprovided the 1 as the yellow-orange oil (1 part by mole)

Vorschrift

To a solution of racemic ethyl 4-amino-3-methoxypiperidine-1-carboxylate (1 part by mole) in DMF were added benzyl bromide (about 2.2 part by mole), potassium carbonate (about 2.4 part by mole) and potassium iodide (about 0.2 part by mole) respectively. The reaction was heated to about 80° C. After about 6 hours, the reaction was slowly diluted with water (about 12 parts by volume) and extracted with, for example, ethyl acetate. The organic layer was washed with brine and then dried over anhyh. Na2SO4. Subsequent filtration and concentration of the solvent provided the 1 as the yellow-orange oil (1 part by mole).

Quelle