Reaktion #667006

Reaktionsgleichung

N-acetyl-2-pyrroline

1,2,3-trimethylbenzene

CH3OH

N-acetyl-2-pyrroline

tetrahydrofuran

→

N-acetylproline methyl ester

Ausbeute 47.9%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeA 70 mL stainless steel high pressure reactor having
2. 2
   Sonstigews pressurized to 1000 psi with CO at room temperature
3. 3
   TemperaturThereafter, the reactor was cooled to room temperature

Vorschrift

A 70 mL stainless steel high pressure reactor having a Pyrex glass liner and a magnetic stir bar was charged with 5 mL of tetrahydrofuran, 0.5 mmol of 1,2,3-trimethylbenzene internal standard, 0.6 mmol of CH3OH, 35.1 mg of (PPh3)2PdCl2, and 55.5 mg of N-acetyl-2-pyrroline. The reactor ws pressurized to 1000 psi with CO at room temperature, and the reaction mixture was stirred for 44.25 hours at 100° C. Thereafter, the reactor was cooled to room temperature and vented to atmospheric pressure. The product mixture was analyzed by gas chromatography and mass spectroscopy, and the analysis indicated complete conversion of N-acetyl-2-pyrroline and a 47.9% yield of N-acetylproline methyl ester.

Quelle