Reaktion #66672

Reaktionsgleichung

2-Isopropyl-4-methoxy-1-(toluene-4-sulfonyl)-benzene

ICl

NaHCO3

→

1-Iodo-4-isopropyl-2-methoxy-5-(toluene-4-sulfonyl)-benzene

Ausbeute 91.8%

Lösungsmittel

HOAc

HOAc

H2O

Reaktionsbedingungen

Aufarbeitung

1. 1
   ExtraktionThe aqueous solution was extracted into EtOAc which
2. 2
   Waschenwas washed with water, brine
3. 3
   Trocknendried over Na2SO4
4. 4
   Filtrationfiltered
5. 5
   Einengenconcentrated in vacuo

Vorschrift

To a solution of 2-Isopropyl-4-methoxy-1-(toluene-4-sulfonyl)-benzene (10 g, 31.25 mmol) in HOAc (10 ml) was added a solution of ICl (9.6 g, 59.26 mmol) in HOAc (10 ml) and H2O (5 ml). The reaction mixture was stirred at room temperature for 16 hrs and basified by saturated NaHCO3 solution. The aqueous solution was extracted into EtOAc which was washed with water, brine, dried over Na2SO4, filtered and concentrated in vacuo to give 1-Iodo-4-isopropyl-2-methoxy-5-(toluene-4-sulfonyl)-benzene (12.35 g, 89%).

Quelle