Reaktion #666574

Reaktionsgleichung

water

3-methylbutane-1,3-diol

4-methylbenzenesulfonyl chloride

→

title compound

Ausbeute 79.0%

3-hydroxy-3-methylbutyl toluene-4-sulfonate

Ausbeute 79.0%

Lösungsmittel

toluene

pyridine

toluene

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto allow for layer separation
2. 2
   WaschenThe obtained organic layer was washed successively with aqueous sulfuric acid and water (twice)
3. 3
   SonstigeThe solvent in the obtained organic layer was evaporated
4. 4
   Sonstigethe residue was azeotropically evaporated with toluene (500 ml)

Vorschrift

Under a nitrogen atmosphere, 3-methylbutane-1,3-diol (300 g) was dissolved in pyridine (900 ml), and a solution of 4-methylbenzenesulfonyl chloride (500 g) in toluene (900 ml) and acetonitrile (125 ml) was added dropwise over 2 hr. The reaction mixture was stirred at room temperature for 4 hr, and toluene (500 ml) and water (1800 ml) were added to allow for layer separation. The obtained organic layer was washed successively with aqueous sulfuric acid and water (twice). The solvent in the obtained organic layer was evaporated, and the residue was azeotropically evaporated with toluene (500 ml) to give the title compound (535 g).

Quelle