Reaktion #66655

Reaktionsgleichung

HCl

3-fluoro-1,4-dimethoxybenzene

DAST

5-(5-Fluoro-2-isopropyl-4-methoxy-phenoxy)-pyrimidine-2,4-diamine

→

5-[5-Chloro-2-(1-fluoro-1-methyl-ethyl)-methoxy-phenoxy]-pyrimidine-2,4-diamine

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeSimilarly prepared

Vorschrift

Similarly prepared, but starting with 3-fluoro-1,4-dimethoxybenzene, and using hydrogenation with Pd/C in step 4 instead of DAST, was 5-(5-Fluoro-2-isopropyl-4-methoxy-phenoxy)-pyrimidine-2,4-diamine (0.778 g, 42%); mp (HCl salt)=239-241° C.; [MH]+=293.

Quelle