Reaktion #666490

Reaktionsgleichung

DIPEA

4-Bromo-3-methoxyphenol

tert-Butylchlorodimethylsilane

→

(4-Bromo-3-methoxyphenoxy)(tert-butyl)dimethylsilane

Lösungsmittel

DCM

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionthe organic layer was extracted
2. 2
   Trocknenthen dried over sodium sulfate
3. 3
   Einengenconcentrated

Vorschrift

4-Bromo-3-methoxyphenol (254 g, 1251 mmol) was dissolved in DCM (2500 mL) and treated with DIPEA (437 mL, 2502 mmol) under nitrogen atmosphere. tert-Butylchlorodimethylsilane (198 g, 1314 mmol) was added and the reaction mixture was stirred at room temperature overnight. The crude product was diluted with water and the organic layer was extracted then dried over sodium sulfate and concentrated.

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