Reaktion #666157

Reaktionsgleichung

TFA

6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid

(4-methylmorpholin-2-yl)methanamine

→

title compound

6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)-N-((4-methylmorpholin-2-yl)methyl)nicotinamide

Reaktionsbedingungen

Vorschrift

The title compound, as a TFA salt, was prepared in a manner similar to Example 74 using 6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and (4-methylmorpholin-2-yl)methanamine 1H NMR (400 MHz, DMSO-d6) δ ppm 2.44 (s, 3 H) 2.78-2.94 (m, 4 H) 2.98-3.15 (m, 1 H) 3.31-3.58 (m, 4 H) 3.68 (t, J=11.75 Hz, 1 H) 3.78-3.95 (m, 1 H) 4.08 (dd, J=12.88, 3.03 Hz, 1 H) 7.67 (d, J=8.08 Hz, 1 H) 7.74 (s, 1 H) 7.78 (br. s., 1 H) 8.21 (d, J=6.32 Hz, 1 H) 8.44 (d, J=7.07 Hz, 2 H) 8.85-9.06 (m, 2 H) 9.93 (br. s., 1 H) 12.57-13.73 (m, 1 H). MS m/z [M+H]+ 433.2.

Quelle