Reaktion #66577

Reaktionsgleichung

Sodium hydride

4-BOC-piperazinone

benzyl bromide

→

sub-title compound

3-oxo-4-(phenylmethyl)-1-piperazinecarboxylic Acid, 1,1-dimethylethyl Ester

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGthe mixture stirred at room temp for 16 h
2. 2
   SonstigeThe reaction was quenched with methanol
3. 3
   workup.ADDITIONdiluted with water
4. 4
   Extraktionextracted with EtOAC
5. 5
   EinengenThe organic extracts were concentrated in vacuo
6. 6
   Sonstigethe residue was purified by chromatography (silica, 20% ether/hexane as eluent)

Vorschrift

Sodium hydride (88 mg, 60% wt.) was added portionwise to a solution of 4-BOC-piperazinone (400 mg) in DMF (10 ml). The reaction mixture was stirred for 1 h, and then benzyl bromide (262 μl) was added dropwise and the mixture stirred at room temp for 16 h. The reaction was quenched with methanol and diluted with water, and then extracted with EtOAC. The organic extracts were concentrated in vacuo and the residue was purified by chromatography (silica, 20% ether/hexane as eluent) to give the sub-title compound (429 mg).

Quelle