Reaktion #66572

ord-a796f8d0917943a8b1bfd61a8446946a

Reaktionsgleichung

CCOC(=O)COc1ccc(C(C)C)cc1CN1CCN(S(=O)(=O)c2ccccc2)CC1
product
CCOC(=O)COc1ccc(C(C)C)cc1CN1CCN(S(=O)(=O)c2ccccc2)CC1
Ethyl[4-(1-methylethyl)-2-[[4-(phenylsulfonyl)-1-piperazinyl]methyl]phenoxy]-acetate
[Na+].[OH-]
NaOH
→
CC(C)c1ccc(OCC(=O)[O-])c(CN2CCN(S(=O)(=O)c3ccccc3)CC2)c1.[Na+]
title compound
CC(C)c1ccc(OCC(=O)[O-])c(CN2CCN(S(=O)(=O)c3ccccc3)CC2)c1.[Na+]
Sodium[4-(1-methylethyl)-2-[[4-(phenylsulfonyl)-1-piperazinyl]methyl]phenoxy]-acetate

Edukte

CCOC(=O)COc1ccc(C(C)C)cc1CN1CCN(S(=O)(=O)c2ccccc2)CC1
product
CCOC(=O)COc1ccc(C(C)C)cc1CN1CCN(S(=O)(=O)c2ccccc2)CC1
Ethyl[4-(1-methylethyl)-2-[[4-(phenylsulfonyl)-1-piperazinyl]methyl]phenoxy]-acetate
[Na+].[OH-]
NaOH

Reagenzien

Keine

Lösungsmittel

C1CCOC1
THF
CO
MeOH

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe solvent was removed in vacuo
  2. 2
    Sonstigethe residue triturated with ether

Vorschrift

A solution of the product from step (e) (113 mg) in NaOH (0.25 ml, 1M), THF (1.5 ml) and MeOH (1 ml) was stirred for 4 h. The solvent was removed in vacuo and the residue triturated with ether to give the title compound (97 mg)

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08524715B2uspto-grants-2013_09