Reaktion #66562

ord-e7091d114b1c4a9aaff93d27c0f7f09c

Reaktionsgleichung

C[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H](C)N1
(3R,5S)-3,5-dimethyl-1-piperazinecarboxylic acid, 1,1-dimethylethyl ester
O=C(Cl)Cc1ccccc1
phenyl acetyl chloride
→
C[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H](C)N1C(=O)Cc1ccccc1
sub-title compound
C[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H](C)N1C(=O)Cc1ccccc1
(3R,5S)-3,5-dimethyl-4-(phenylacetyl)-1-piperazinecarboxylic Acid, 1,1-dimethylethyl Ester

Edukte

—
( a )
C[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H](C)N1
(3R,5S)-3,5-dimethyl-1-piperazinecarboxylic acid, 1,1-dimethylethyl ester
O=C(Cl)Cc1ccccc1
phenyl acetyl chloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Prepared by the method of example 67 part (a) using (3R,5S)-3,5-dimethyl-1-piperazinecarboxylic acid, 1,1-dimethylethyl ester and phenyl acetyl chloride to give the sub-title compound.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08524715B2uspto-grants-2013_09