Reaktion #66561

ord-0362b148b29e4e6a8d6012284df9cda1

Reaktionsgleichung

CCC[C@H]1CN(Cc2cc(Cl)ccc2OCC(=O)O)CCN1S(=O)(=O)c1ccccc1
product
CCC[C@H]1CN(Cc2cc(Cl)ccc2OCC(=O)O)CCN1S(=O)(=O)c1ccccc1
[4-Chloro-2-[[(3S)-4-(phenylsulfonyl)-3-propyl-1-piperazinyl]methyl]phenoxy]-acetic Acid
O=C(Cl)Cc1ccccc1
phenylacetyl chloride
→
CCC[C@H]1CN(Cc2cc(Cl)ccc2OCC(=O)O)CCN1C(=O)Cc1ccccc1
title compound
CCC[C@H]1CN(Cc2cc(Cl)ccc2OCC(=O)O)CCN1C(=O)Cc1ccccc1
[4-Chloro-2-[[(3S)-4-(phenylacetyl)-3-propyl-1-piperazinyl]methyl]-phenoxy]-acetic Acid

Edukte

—
( g )
—
( f )
CCC[C@H]1CN(Cc2cc(Cl)ccc2OCC(=O)O)CCN1S(=O)(=O)c1ccccc1
product
CCC[C@H]1CN(Cc2cc(Cl)ccc2OCC(=O)O)CCN1S(=O)(=O)c1ccccc1
[4-Chloro-2-[[(3S)-4-(phenylsulfonyl)-3-propyl-1-piperazinyl]methyl]phenoxy]-acetic Acid
O=C(Cl)Cc1ccccc1
phenylacetyl chloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Prepared from the product from example 72 part (f) (0.70 g) and phenylacetyl chloride according to the procedure described in example 69 part (g) to give the title compound as a white solid (214 mg).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08524715B2uspto-grants-2013_09