Reaktion #66550

Reaktionsgleichung

Diisopropylethylamine

trans-2,5-dimethyl-piperazine

phenyl acetic acid

HATU

→

sub-title compound

Ausbeute 178.8%

2,5-dimethyl-1-(phenylacetyl)-piperazine

Ausbeute 178.8%

Lösungsmittel

water

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with ethyl acetate
2. 2
   TrocknenThe organic extracts were dried (MgSO4)
3. 3
   Einengenthen concentrated in vacuo

Vorschrift

Diisopropylethylamine (0.38 ml) was added to a solution of trans-2,5-dimethyl-piperazine (1.50 g), phenyl acetic acid (0.59 g) and HATU (1.55 g) in DMF (10 ml). The reaction mixture was stirred overnight at ambient temperature. The solution was diluted with water, then extracted with ethyl acetate. The organic extracts were dried (MgSO4) then concentrated in vacuo to give the sub-title compound (1.8 g).

Quelle