Reaktion #66544

ord-4ce17325f6504feaab3e708fcc28b51d

Reaktionsgleichung

CC1CN(S(=O)(=O)c2ccccc2)CCN1Cc1cc(Cl)ccc1OCC(=O)O
product
CC1CN(S(=O)(=O)c2ccccc2)CCN1Cc1cc(Cl)ccc1OCC(=O)O
[4-Chloro-2-[[2-methyl-4-(phenylsulfonyl)-1-piperazinyl]methyl]phenoxy]acetic Acid
O=S(=O)(Cl)Cc1ccccc1
benzenemethanesulfonyl chloride
→
CC1CN(S(=O)(=O)Cc2ccccc2)CCN1Cc1cc(Cl)ccc1OCC(=O)O
title compound
CC1CN(S(=O)(=O)Cc2ccccc2)CCN1Cc1cc(Cl)ccc1OCC(=O)O
[4-Chloro-2-[[2-methyl-4-[(phenylmethyl)sulfonyl]-1-piperazinyl]methyl]phenoxy]acetic Acid

Edukte

CC1CN(S(=O)(=O)c2ccccc2)CCN1Cc1cc(Cl)ccc1OCC(=O)O
product
CC1CN(S(=O)(=O)c2ccccc2)CCN1Cc1cc(Cl)ccc1OCC(=O)O
[4-Chloro-2-[[2-methyl-4-(phenylsulfonyl)-1-piperazinyl]methyl]phenoxy]acetic Acid
—
( b )
O=S(=O)(Cl)Cc1ccccc1
benzenemethanesulfonyl chloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigePrepared by the method of example 30

Vorschrift

Prepared by the method of example 30, using the product of example 53 part (b) and benzenemethanesulfonyl chloride to give the title compound.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08524715B2uspto-grants-2013_09