Reaktion #66513

Reaktionsgleichung

4-iodo-1H-pyrazole

1-(chloromethyl)-4-methoxybenzene

K2CO3

→

4-iodo-1-(4-methoxybenzyl)-1H-pyrazole

Ausbeute 88.2%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture was cooled to room temperature
2. 2
   Filtrationwas filtered
3. 3
   EinengenThe filtrate was concentrated under reduced pressure
4. 4
   SonstigeThe crude product was purified by flash chromatography over silica gel

Vorschrift

According to Scheme 6 Step 1: A suspension of 4-iodo-1H-pyrazole (26.3 mmol, 5.11 g), 1-(chloromethyl)-4-methoxybenzene (29.0 mmol, 3.95 mL) and K2CO3 (39.5 mmol, 5.46 g) in acetonitrile (150 mL) was heated at 60° C. overnight. The reaction mixture was cooled to room temperature and was filtered. The filtrate was concentrated under reduced pressure. The crude product was purified by flash chromatography over silica gel using DCM as eluent to afford 4-iodo-1-(4-methoxybenzyl)-1H-pyrazole (23.2 mmol, 7.3 g, 88%) as a yellow solid.

Quelle