Reaktion #66512

Reaktionsgleichung

4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-(pyridin-2-ylamino)thiazol-5-carbonitrile

Na2CO3

water

→

4-(1H-pyrazol-4-yl)-2-(pyridin-2-ylamino)thiazol-5-carbonitrile

Ausbeute 26.0%

Lösungsmittel

TFA

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe aqueous phase was filtered
2. 2
   Sonstigeto afford a brown solid which
3. 3
   Sonstigewas recrystallized thrice with DMF/water

Vorschrift

According to Scheme 5 Step 3: A solution of 4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-(pyridin-2-ylamino)thiazol-5-carbonitrile (0.93 mmol, 360 mg) in TFA (3 mL) was microwaved for 5 min at 140° C. The reaction mixture was neutralized with a saturated solution of Na2CO3 (40 mL) and water (50 mL). The aqueous phase was filtered to afford a brown solid which was recrystallized thrice with DMF/water to yield 4-(1H-pyrazol-4-yl)-2-(pyridin-2-ylamino)thiazol-5-carbonitrile (0.24 mmol, 65 mg, 26%) as an off-white solid.

Quelle