Reaktion #66510

Reaktionsgleichung

N-(4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)thiazol-2-yl)pyridin-2-amine

N-chlorosuccinimide

→

N-(4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-5-chlorothiazol-2-yl)pyridin-2-amine

Ausbeute 84.1%

Lösungsmittel

AcOEt

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenthe organic phase was washed with a saturated solution of Na2CO3
2. 2
   TrocknenThe organic phase was dried over MgSO4
3. 3
   Filtrationwas filtered
4. 4
   Einengenwas concentrated

Vorschrift

According to Scheme 4 Step 1 Method A: A solution of N-(4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)thiazol-2-yl)pyridin-2-amine (1.38 mmol, 500 mg) and N-chlorosuccinimide (1.38 mmol, 184 mg) in DMF (3 mL) was stirred for 1 hour at 50° C. The reaction mixture was diluted with AcOEt (250 mL) and the organic phase was washed with a saturated solution of Na2CO3. The organic phase was dried over MgSO4, was filtered and was concentrated to yield N-(4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-5-chlorothiazol-2-yl)pyridin-2-amine (1.16 mmol, 460 mg, 84%) as a beige solid.

Quelle