Reaktion #66491

Reaktionsgleichung

(R)-2-aminopropanol

2,4-dichloro-5-iodopyrimidine

triethylamine

→

title compound

Ausbeute 88.0%

(R)-2-(2-chloro-5-iodopyrimdin-4-ylamino)propan-1-ol

Ausbeute 88.0%

Lösungsmittel

ethyl acetate

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionfollowed by extraction with brine, 10% aqueous citric acid, and aqueous sodium bicarbonate
2. 2
   TrocknenAfter drying over sodium sulfate
3. 3
   Sonstigethe solvent was evaporated
4. 4
   Sonstigethe residue was purified by column chromatography

Vorschrift

To a solution of 2,4-dichloro-5-iodopyrimidine (3.0 g; 10.9 mol) in acetonitrile (35 mL) was added triethylamine (1.32 g, 1.82 mL, 13.1 mmol), followed by (R)-2-aminopropanol (0.88 g, 11.8 mmol). The mixture was stirred at room temperature for 24 h and was then diluted with ethyl acetate, followed by extraction with brine, 10% aqueous citric acid, and aqueous sodium bicarbonate. After drying over sodium sulfate, the solvent was evaporated and the residue was purified by column chromatography to give the title compound (3.0 g, 88% yield).

Quelle