Reaktion #66458

ord-5c39562b757e41e2b43bc8e67bd374ae

Reaktionsgleichung

COc1cccc2c(=O)[nH]c(-c3ccccc3C(F)(F)F)nc12
8-methoxy-2-(2-trifluoromethyl-phenyl)-3H-quinazolin-4-one
CCN(CC)CC.Cl
triethylamine hydrochloride
O=P(Cl)(Cl)Cl
POCl3
→
COc1cccc2c(Cl)nc(-c3ccccc3C(F)(F)F)nc12
solid
Ausbeute 89.0%
COc1cccc2c(Cl)nc(-c3ccccc3C(F)(F)F)nc12
4-Chloro-8-methoxy-2-(2-trifluoromethyl-phenyl)-quinazoline
Ausbeute 89.0%

Edukte

COc1cccc2c(=O)[nH]c(-c3ccccc3C(F)(F)F)nc12
8-methoxy-2-(2-trifluoromethyl-phenyl)-3H-quinazolin-4-one
CCN(CC)CC.Cl
triethylamine hydrochloride
O=P(Cl)(Cl)Cl
POCl3

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigePurification by flash chromatography

Vorschrift

Prepared from 8-methoxy-2-(2-trifluoromethyl-phenyl)-3H-quinazolin-4-one (1.0 g, 3.12 mmol), triethylamine hydrochloride (472 mg, 3.43 mmol), and POCl3. Purification by flash chromatography afforded a white solid (89% yield). HPLC-Method A, Rt 4.10 min, (98%), MS (m/z) 258.08 (M+H).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08524720B2uspto-grants-2013_09