Reaktion #66438

Reaktionsgleichung

ethyl 2-amino-4-fluorobenzoate

formamide

ammonium formate

ammonium formate

→

7-fluoro-3-hydroquinazolin-4-one

Lösungsmittel

EtOAc

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with water
2. 2
   Extraktionback-extracted with EtOAc
3. 3
   Sonstigedried
4. 4
   Einengenconcentrated in vacuo

Vorschrift

To a suspension of ethyl 2-amino-4-fluorobenzoate (1.73 g, 9.45 mmol) in formamide (8 mL) was added ammonium formate (0.9 g, 14 mmol). The reaction mixture was stirred at 140° C. for 24 hr, with additional ammonium formate (0.92 g, 15 mmol) at 6 hr. The reaction was dilute with EtOAc, washed with water, back-extracted with EtOAc, dried and concentrated in vacuo to give 7-fluoro-3-hydroquinazolin-4-one (2.82 g) which contains some formamide. ES-MS (M+H)+=165.

Quelle