Reaktion #66435

Reaktionsgleichung

3-aminobenzyl alcohol

acetic anhydride

→

N-[3-(hydroxymethyl)phenyl]acetamide

Ausbeute 85.0%

Lösungsmittel

EtOAc

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with aq. NaOH and brine
2. 2
   Einengenconcentrated in vacuo

Vorschrift

To a chilled suspension of 3-aminobenzyl alcohol (9.24 g, 75 mmol) in THF (50 mL) was added neat acetic anhydride (8.1 mL, 86 mmol). The reaction mixture was stirred cold for 1 hr, diluted with EtOAc, washed with aq. NaOH and brine, and concentrated in vacuo to give N-[3-(hydroxymethyl)phenyl]acetamide (10.5 g, 85%).

Quelle