Reaktion #66396

Reaktionsgleichung

tert-butyl(trans)-2-(1,1′-biphenyl-4-yl)cyclopropyl(2-(4-methylpiperazin-1-yl)-2-oxoethyl)carbamate

Et2O.HCl

→

2-((trans)-2-(1,1′-biphenyl-4-yl)cyclopropylamino)-1-(4-methylpiperazin-1-yl)ethanone

Ausbeute 15.0%

Lösungsmittel

Et2O

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter completion reaction mixture
2. 2
   Filtrationwas filtered under inert atmosphere
3. 3
   Waschenwashed with hexane and EtOAC
4. 4
   Sonstigedried under reduced pressure

Vorschrift

To a solution of tert-butyl(trans)-2-(1,1′-biphenyl-4-yl)cyclopropyl(2-(4-methylpiperazin-1-yl)-2-oxoethyl)carbamate derivative (1 equiv) in Et2O at 0° C. was added Et2O.HCl slowly drop wise, stirred for 1 h at 0° C. to RT. The progress of the reaction was monitored by TLC. After completion reaction mixture was filtered under inert atmosphere and washed with hexane and EtOAC, and dried under reduced pressure to get 2-((trans)-2-(1,1′-biphenyl-4-yl)cyclopropylamino)-1-(4-methylpiperazin-1-yl)ethanone derivative (Overall yield 15%).

Quelle