Reaktion #663474

Reaktionsgleichung

ethyl 7-bromo-3-(3-(naphthalen-1-yloxy)propyl)-1H-indole-2-carboxylate

1-(chloromethyl)-4-methoxybenzene

Cs2CO3

→

ethyl 7-bromo-1-(4-methoxybenzyl)-3-(3-(naphthalen-1-yloxy)propyl)-1H-indole-2-carboxylate

Lösungsmittel

N,N-dimethylamide

ether

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   ExtraktionThe aqueous layer was extracted with ether
2. 2
   WaschenThe combined extracts were washed with water (×3), brine
3. 3
   Trocknendried over Na2SO4
4. 4
   EinengenConcentration
5. 5
   Sonstigegave EXAMPLE 581A

Vorschrift

To a solution of ethyl 7-bromo-3-(3-(naphthalen-1-yloxy)propyl)-1H-indole-2-carboxylate (2.39 g, prepared in a similar manner as described herein) in N,N-dimethylamide (20 mL) was added 1-(chloromethyl)-4-methoxybenzene (1.0 g) and Cs2CO3 (5.16 g). The mixture was stirred overnight at room temperature. The mixture was diluted with ether (300 mL) and water (200 mL). The aqueous layer was extracted with ether. The combined extracts were washed with water (×3), brine and dried over Na2SO4. Concentration gave EXAMPLE 581A.

Quelle