Reaktion #66293

Reaktionsgleichung

methyl 2-hydroxybenzoate

n-propylamine

→

2-hydroxy-N-propylbenzamide

Ausbeute 84.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction mixture was concentrated under reduced pressure
2. 2
   Sonstigeto give the crude material that
3. 3
   Sonstigewas purified by silica gel flash column chromatography

Vorschrift

The crude methyl 2-hydroxybenzoate was dissolved in n-propylamine (400 mL). The reaction mixture in a sealed reactor was stirred at 80° C. overnight. The reaction mixture was concentrated under reduced pressure to give the crude material that was purified by silica gel flash column chromatography to afford 120 g (84%) of 2-hydroxy-N-propylbenzamide. LCMS ESI (+) m/z 180 (M+1) detected.

Quelle