Reaktion #662791

Reaktionsgleichung

HCl

Ethylsulfonyl chloride

3-bromo-4-(2,4-difluorophenoxy)aniline

pyridine

→

title compound

Ausbeute 99.7%

N-[3-bromo-4-(2,4-difluorophenoxy)phenyl]ethanesulfonamide

Ausbeute 99.7%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with dichloromethane (3×10 ml)
2. 2
   Waschenthe combined organic extracts were washed with saturated bicarbonate solution (aq)
3. 3
   Trocknendried over sodium sulfate
4. 4
   Filtrationfiltered
5. 5
   Einengenconcentrated in vacuo

Vorschrift

Ethylsulfonyl chloride (177 mg, 1.4 mmol) was added dropwise to a stirred solution of 3-bromo-4-(2,4-difluorophenoxy)aniline (328 mg, 1.1 mmol) and pyridine (178 μL, 2.2 mmol) in dichloromethane (2 ml) at 0° C. under nitrogen. After the mixture was allowed to warm to rt and stir overnight, it was treated with 1N HCl (10 ml) and extracted with dichloromethane (3×10 ml); the combined organic extracts were washed with saturated bicarbonate solution (aq), dried over sodium sulfate, filtered and concentrated in vacuo to give the title compound (430 mg, 99%) as a tan solid which was carried forward without purification. LCMS (M−H)−=391.

Quelle