Reaktion #662674

ord-389c1c042b894da79b635e87f8929ab0

Reaktionsgleichung

NC(=O)c1nn2c(c1C(F)(F)F)C(F)(F)COc1ccc(I)cc1-2
4,4-difluoro-9-iodo-3-(trifluoromethyl)-4,5-dihydrobenzo[b]pyrazolo[1,5-d][1,4]oxazepine-2-carboxamide
C#C[C@]1(O)CCN(C)C1=O
(R)-3-ethynyl-3-hydroxy-1-methylpyrrolidin-2-one
→
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-n2nc(C(N)=O)c(C(F)(F)F)c2C(F)(F)CO3)C1=O
titled compound
CN1CC[C@@](O)(C#Cc2ccc3c(c2)-n2nc(C(N)=O)c(C(F)(F)F)c2C(F)(F)CO3)C1=O
(R)-4,4-difluoro-9-((3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl)ethynyl)-3-(trifluoromethyl)-4,5-dihydrobenzo[b]pyrazolo[1,5-d][1,4]oxazepine-2-carboxamide

Edukte

NC(=O)c1nn2c(c1C(F)(F)F)C(F)(F)COc1ccc(I)cc1-2
4,4-difluoro-9-iodo-3-(trifluoromethyl)-4,5-dihydrobenzo[b]pyrazolo[1,5-d][1,4]oxazepine-2-carboxamide
C#C[C@]1(O)CCN(C)C1=O
(R)-3-ethynyl-3-hydroxy-1-methylpyrrolidin-2-one

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Similar to as described in General Procedure G, 4,4-difluoro-9-iodo-3-(trifluoromethyl)-4,5-dihydrobenzo[b]pyrazolo[1,5-d][1,4]oxazepine-2-carboxamide was reacted with (R)-3-ethynyl-3-hydroxy-1-methylpyrrolidin-2-one to give a titled compound after purification by HPLC.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09034866B2uspto-grants-2015_05