Reaktion #662668

Reaktionsgleichung

9-iodo-4,4-difluoro-4,5-dihydrobenzo[b]pyrazolo[1,5-d][1,4]oxazepine-2-carboxamide

(R)-3-ethynyl-3-hydroxypyrrolidin-2-one

→

titled compound

(R)-4,4-difluoro-9-((3-hydroxy-2-oxopyrrolidin-3-yl)ethynyl)-4,5-dihydrobenzo[b]pyrazolo[1,5-d][1,4]oxazepine-2-carboxamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto give

Vorschrift

Similar to as described in General Procedure G, 9-iodo-4,4-difluoro-4,5-dihydrobenzo[b]pyrazolo[1,5-d][1,4]oxazepine-2-carboxamide was reacted with (R)-3-ethynyl-3-hydroxypyrrolidin-2-one to give a mixture of titled compound after purification by prep HPLC.

Quelle