Reaktion #66172

Reaktionsgleichung

compound

Ethyl (5-bromopyridin-3-yl)acetate

dimethylformamide diethyl acetal

→

Ethyl 3-(dimethylamino)-2-(5-bromopyridin-3-yl)acrylate

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling
2. 2
   Einengenthe mixture is concentrated under reduced pressure
3. 3
   Filtrationthe solid is filtered off
4. 4
   Waschenfinally washed with diisopropyl ether
5. 5
   TrocknenThe crude product is dried under reduced pressure for 16 h.

Vorschrift

5.1 g (20.9 mmol) of the compound from Example 10A are stirred in 7.2 ml (6.2 g, 41.8 mmol) of dimethylformamide diethyl acetal at a bath temperature of 100° C. for 16 h. After cooling, the mixture is concentrated under reduced pressure, the residue is stirred in diisopropyl ether, and the solid is filtered off and finally washed with diisopropyl ether. The crude product is dried under reduced pressure for 16 h.

Quelle